RegisterLogin

CHNQD-03301

CAT: 0804-HY-179341Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179341Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
CHNQD-03301 is an orally active hypoxia-inducible factor-1α (HIF-1α) inhibitor (IC50 = 10.97 nM) . CHNQD-03301 promotes the proteasomal degradation of HIF-1α protein, leading to its significant suppression. CHNQD-03301 can reverse HIF accumulation-induced angiogenesis and mitigate the HIF-induced erythrocytosis phenotype in zebrafish models. CHNQD-03301 can be used for the study of colon cancer[1].
CAS Number
[3104302-65-7]
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
OC1=CC=C(C2=CC(OC)=C3C(OC4=CC(OC(C)(C)O5)=C5C=C34)=C2OC)C=C1
Molecular Formula
C23H20O6
Molecular Weight
392.40
References & Citations
[1]Wang CF, et al. Discovery of Oral Natural Benzofuranoid p-Terphenyl Derivative CHNQD-03301 as a Potent Hypoxia-Inducible Factor-1α Signaling Inhibitor for Cancer Therapy. J Med Chem. 2025 Nov 13;68 (21) :22988-23005.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIF-1α

Related Products

CatalogName
HY-177270CHNQD-01281
HY-177269CHNQD-01269
HY-177268CHNQD-01426
HY-177869-01CHNQD-00824
HY-151461CHNQD-01255
HY-153833-01PDS-0330
HY-134885-01RMC-0331

Alternative Products

CatalogName
T62151-01CHNQD-01255

Popular Products