CHNQD-01281

CAT: 0804-HY-177270Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-177270Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHNQD-01281, a derivative of Brefeldin A (HY-16592), is a EGFR modulator. CHNQD-01281 has strong antiproliferative activities against cancer cells (IC50: 0.079 and 0.081 μM for T24 and J82 cells, respectively) . CHNQD-01281 regulates both EGFR/PI3K/AKT and EGFR/ERK pathways and mediates the chemotactic effect of chemokines on immune effector cells. CHNQD-01281 remarkably inhibits tumor growth in T24 xenograft mice model and prolongs the survival time in MB49 allogeneic mice model via inducing infiltration of cytotoxic T cells[1].
CAS Number
[2762488-97-9]
UNSPSC
12352005
Target
Drug Derivative; EGFR
Related Pathways
JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O[C@@H]1C[C@]2([H])[C@@](/C=C/CCC[C@H](C)OC(/C=C/[C@H]2OC(/C=C/C3=CN=CC=C3)=O)=O)([H])C1
Molecular Formula
C24H29NO5
Molecular Weight
411.49
References & Citations
[1]Liu JY, et al. Discovery of a potential bladder cancer inhibitor CHNQD-01281 by regulating EGFR and promoting infiltration of cytotoxic T cells. Mar Life Sci Technol. 2024 Aug 5;6 (3) :502-514.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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