CHNQD-01426

CAT: 0804-HY-177268Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-177268Size:1 Each
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Description
CHNQD-01426 (Compound 4a) is an anticancer agent. CHNQD-01426 has cytotoxic activities against cancer cells. CHNQD-01426 significantly inhibits hepatocellular carcinoma cells proliferation via arresting S and G2/M phase cell cycle and induces apoptosis by inducing ROS production and elevating apoptosis-related proteins expression. CHNQD-01426 potently inhibits tumor growth in HepG2 xenograft mice model[1][2].
CAS Number
[2673232-30-7]
UNSPSC
12352005
Target
Akt; Apoptosis; Caspase; PARP; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1NC(C(C2=CC(OC)=C(OC)C(OC)=C2)=O)=NC3=CC=CC=C31
Molecular Formula
C18H16N2O5
Molecular Weight
340.33
References & Citations
[1]Wang CJ, et al. Discovery of penipanoid C-inspired 2- (3,4,5-trimethoxybenzoyl) quinazolin-4 (3H) -one derivatives as potential anticancer agents by inhibiting cell proliferation and inducing apoptosis in hepatocellular carcinoma cells. Eur J Med Chem. 2021 Nov 15;224:113671. |[2]Zhang Q, et al. Recent advances of bioactive marine natural products in drug discovery[J]. Journal of Ocean University of China, 2024, 23 (5) : 1297-1318.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase 3

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