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DEL-C1

CAT: 0804-HY-179214Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179214Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DEL-C1 is a CHI3L1 inhibitor. DEL-C1 can restore the ability to clear Amyloid-β and repair lysosomal function of astrocytes. DEL-C1 can inhibit NF-κB signaling and IL-6 secretion. DEL-C1 can be used for the researches of inflammation and neurological disease, such as Alzheimer's disease[1].
UNSPSC
12352100
Target
Amyloid-β; Glycosidase; Interleukin Related; NF-κB
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CNC(C[C@H](C1=CC=CC=C1)NC(C[C@@H](NC([C@@H]2CCCC[C@H]2NCC3=CN=C(O3)C4=C(N=C(S4)C)C)=O)CC5=CNC6=C5C=CC=C6)=O)=O
Molecular Formula
C38H45N7O4S
Molecular Weight
695.87
References & Citations
[1]Kaur B, et al. Discovery of a CHI3L1-Targeted Small Molecule Modulating Neuroinflammation in Alzheimer's Disease via DNA-Encoded Library (DEL) Screening †. bioRxiv [Preprint]. 2025 Oct 21:2025.10.20.683491.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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