DEL-S1

• Description :

  DEL-S1 is a SLIT2 binder. DEL-S1 significantly impairs SLIT2/ROBO1 complex formation by inducing conformational rearrangements, further inhibits its function with an IC50 of 68.8 μM. DEL-S1 can be used for neural development, immune regulation and cancers like glioblastoma research[1].

• UNSPSC :

  12352005

• Target :

  Others

• Related Pathways :

  Others

• Field of Research :

  Cancer; Inflammation/Immunology; Neurological Disease

• Purity :

  98.0100

• Smiles :

  N#CC1=CC=CC=C1N(CC2)CCN2C3=NC(N(CC)C4CCCCC4)=NC(N[C@@H](C(NC)=O)CC(N)=O)=N3

• Molecular Formula :

  C27H38N10O2

• Molecular Weight :

  534.66

• References & Citations :

  [1]Yuan S, et al. Discovery of a First-in-Class SLIT2 Binder Disrupting the SLIT2/ROBO1 Axis via DNA-Encoded Library (DEL) Screening. bioRxiv [Preprint]. 2025 Jun 22:2025.06.22.660907.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported