PLK4-IN-5

• Description:

  PLK4-IN-5 is a PLK4 (IC50 = 0.8 nM) inhibitor. PLK4-IN-5 can inhibit MCF-7 cell clone formation, induce cell cycle arrest (S/G2 phase), and apoptosis. PLK4-IN-5 has anti proliferative activity against MCF-7 cells (IC50 = 0.48 μM) . PLK4-IN-5 can be used in the research of cancer such as breast cancer[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Polo-like Kinase (PLK)

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Smiles:

  NC1=CC=C(C=C1)SC2=NC(NC3=CC=C(C=C3)NC4CCS(=O)(CC4)=O)=NC=C2Cl

• Molecular Formula:

  C21H22ClN5O2S2

• Molecular Weight:

  476.01

• References & Citations:

  [1]Mu S, et al. Design, synthesis, and biological evaluation of 5-chlorine-2-amino-pyrimidine derivatives as potent PLK4 inhibitors. RSC Med Chem. 2025 Aug 14.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported