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NS2B/NS3-IN-9

CAT: 0804-HY-179013Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179013Size:1 Each
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Description
NS2B/NS3-IN-9 (Compound 73) is a broad-spectrum, non-competitive anti-Orthoflavivirus lipopeptide inhibitor targeting the NS2B-NS3 protease. NS2B/NS3-IN-9 exhibits IC50 values for Dengue virus DENV2 NS2B-NS3, West Nile virus WNV NS2B-NS3, and Zika virus ZIKV NS2B-NS3 of 2.4, 7.2, and 1.9 μM, respectively. NS2B/NS3-IN-9 also exhibits antiviral activity at the cellular level against DENV2, WNV, and ZIKV, with EC50 values of 4.1, 4.9, and 5.0 μM, respectively. NS2B/NS3-IN-9 has no significant toxicity to cells. NS2B/NS3-IN-9 can be used for the study of anti-Orthoflavivirus[1].
CAS Number
812683-94-6
UNSPSC
12352211
Target
Dengue Virus; Flavivirus; Virus Protease
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
CCCCCCCCCCCCCCCC(N[C@H](C(N[C@H](C(N[C@@H](C(N[C@H](C(N)=O)CCCCN)=O)C)=O)C)=O)CCCCN)=O
Molecular Formula
C34H67N7O5
Molecular Weight
653.94
References & Citations
[1]Cavina L, et al. Development of Lipopeptides as Orthoflavivirin Inhibitors with Low Micromolar Broad-Spectrum Antiorthoflaviviral Activity. J Med Chem. 2025 Nov 13;68 (21) :22386-22400.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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