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BJH-86

CAT: 0804-HY-178987Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178987Size:1 Each
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Description
BJH-86 is a soluble mitochondrial complex 1 inhibitor (oxygen consumption rate inhibition IC50 = 5 μM) . BJH-86 exhibits weak inhibitory activity against phosphodiesterase 10A (PDE10A) (IC50 >10 μM) . BJH-86 can reduce cellular oxygen consumption and inhibit cancer cell proliferation. BJH-86 can be used for the research of cancer, such as lung cancer[1].
CAS Number
3067849-10-6
UNSPSC
12352005
Target
Mitochondrial Metabolism; Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
COC1=CC=C2N=CC=C(CC3=CC=CC(C4=CN(C5COC5)N=C4)=C3)C2=C1
Molecular Formula
C23H21N3O2
Molecular Weight
371.43
References & Citations
[1]Haines BJ, et al. Development of Selective and Soluble Mitochondrial Complex 1 Inhibitors Derived from Papaverine for Radiosensitization of Cancer. J Med Chem. 2025 Oct 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE10

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