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SRS16-86

CAT: 0804-HY-135430-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-135430-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SRS16-86 is a potent inhibitor of ferroptosis[1]. SRS16-86 is more stable than more stable to metabolism and plasma than Ferrostatin-1 in vivo. SRS16-86 can be used for renal ischemia-reperfusion injury (IRI) and spinal cord injury (SCI) research[2][3].
CAS Number
1793052-96-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/srs16-86.html
Purity
98.0
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(C1=CC(/N=C\C2=CN=CN=C2)=C(C=C1)NC3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3)OC(C)(C)C
Molecular Formula
C26H32N4O2
Molecular Weight
432.56
Precautions
H302, H315, H319, H335
References & Citations
[1]Sam Hofmans, et al. Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties. J Med Chem. 2016 Mar 10;59 (5) :2041-53.|[2]Andreas Linkermann, et al. Synchronized renal tubular cell death involves ferroptosis.Proc Natl Acad Sci U S A. 2014 Nov 25;111 (47) :16836-41.|[3]Yan Zhang, et al. Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury. Brain Res. 2019 Mar 1;1706:48-57.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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