NM-001

CAT: 0804-HY-178819Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-178819Size:1 Each

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Description

NM-001 is a theranostic prodrug that targets ανβ3 integrin. NM-001 consists of cRGD and GFLG peptides, a DCM fluorophore and Chlorambucil. NM-001 internalizes into lysosomes of tumor cells via the cRGD peptide, and generates NM-002 (HY-178820) and Chlorambucil through intracellular cleavage at the GFLG peptide by overexpressed Cathepsin B (CTSB). NM-001 exhibits green fluorescence under physiological conditions, and converts to NIR fluorescence by CTSB activation. NM-001 has significant antitumor activity with low toxicity in HeLa cell xenografts mouse models. NM-001 can be used for real-time drug release monitoring research[1].

UNSPSC

12352005

Target

Drug Intermediate; Integrin

Related Pathways

Cytoskeleton; Others

Field of Research

Cancer

Smiles

CC(C)(C1=C(C=C(C/2=C1)OC(/C=C/C3=CC(Cl)=C(C(COC(CCCC4=CC=C(C=C4)N(CCCl)CCCl)=O)=C3)OCC5=CC=C(C=C5)NC(CNC([C@H](NC([C@H](NC(CN)=O)CC6=CC=CC=C6)=O)CC(C)C)=O)=O)=CC2=C(C#N)\C#N)OCCOCCOCCOCCN7N=NC(CCC(NCCCC[C@@H](C(N[C@H]8CCCNC(N)=N)=O)NC([C@H](NC([C@@H](NC(CNC8=O)=O)CC(O)=O)=O)CC9=CC=C(C=C9)O)=O)=O)=C7)C

Molecular Formula

C105H131Cl3N20O21

Molecular Weight

2115.64

References & Citations

[1]Zhai W, et al. Cathepsin B-Activated Prodrug for Precision Tumor Theranostics. J Med Chem. 2025 Oct 23;68 (20) :21829-21839.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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HY-P991239	NM-02
HY-13705-01	NM-3
HY-P991357	STT-001
HY-172232	STG-001
HY-W662576	KVD-001
HY-W140974-01	SN-001
HY-124717-01	YC-001
HY-136637-01	NPD-001
HY-178820	NM-002
HY-178217	JSSW-001

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NM-001

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