NM-001

CAT: 0013-GTR19273540-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19273540-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

NM-001 is a theranostic prodrug that targets ανβ3 integrin. It consists of cRGD peptides, GFLG peptides, a dichloromethane fluorophore, and Chlorambucil. The compound enters tumor cell lysosomes through cRGD peptides, where overexpressed cathepsin B (CTSB) facilitates intracellular cleavage of GFLG peptides, generating NM-002 and Chlorambucil. Under physiological conditions, NM-001 exhibits green fluorescence, which switches to near-infrared fluorescence upon CTSB activation. In a HeLa cell xenograft mouse model, NM-001 demonstrates significant antitumor activity with reduced toxicity and is suitable for real-time drug release monitoring studies.

Storage Conditions

-20°C

Notes

For research use only.

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NM-001

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