CT 32228

CAT: 0804-HY-178712Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-178712Size:1 Each
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Description
CT 32228 is an inhibitor of lysophosphatidic acid acyltransferase-β (LPAAT-β) . CT 32228 inhibits tumor cell growth. CT 32228 exhibits IC50 values of around 0.1-0.8 μM in various leukemia cell lines. CT 32228 induces caspase activation in DHL-4 and Ramos cells. CT 32228 induces apoptosis when combined with Rituximab (HY-P9913) . CT 32228 results in a 50% xenograft growth delay in vivo. CT 32228 can be studied in research on acute leukemia[1][2].
CAS Number
[521064-34-6]
UNSPSC
12352005
Target
Apoptosis
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
ClC1=CC(C2=NC(NC3=CC=C(C=C3)Br)=NC(N)=N2)=C(C)C=C1
Molecular Formula
C16H13BrClN5
Molecular Weight
390.66
References & Citations
[1]Douvas MG, et al., Effect of lysophosphatidic acid acyltransferase-beta inhibition in acute leukemia. Leuk Res. 2006 Aug;30 (8) :1027-36.|[2]Pagel JM, et al., Induction of apoptosis using inhibitors of lysophosphatidic acid acyltransferase-beta and anti-CD20 monoclonal antibodies for treatment of human non-Hodgkin's lymphomas. Clin Cancer Res. 2005 Jul 1;11 (13) :4857-66.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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