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WRN-IN-20

CAT: 0804-HY-178474Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178474Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WRN inhibitor 20 (Compound 14c) is a WRN degradation agent. WRN inhibitor 20 exhibits strong degradation activity in various cells, such as HCT-116 (DC50 = 1.7 µM), SW-48 (DC50 = 3.0 µM), and SW-480 (DC50 = 5.9 µM) cells. WRN inhibitor 20 exhibits potent anti proliferative, pro apoptotic, migration inhibiting, and DNA damage inducing effects in MSI-H cells. WRN inhibitor 20 can be used for research on cancer[1].
CAS Number
3095277-20-3
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NCCCCCOC1=CC=C(C2=NC(S(=O)(NCC(NC3=CC=C(C)C=C3)=O)=O)=NC(C(F)(F)F)=C2)C=C1)CC45C[C@H](C6)C[C@@H](C5)C[C@H]6C4
Molecular Formula
C37H44F3N5O5S
Molecular Weight
727.84
References & Citations
[1]Tao W, et al. Targeted degradation of Werner syndrome helicase (WRN) via ligand-directed covalent hydrophobic tagging. Eur J Med Chem. 2025 Dec 15;300:118121.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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