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WRN-IN-19

CAT: 0804-HY-174217Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174217Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WRN-IN-19 (Compound (S) -27) is a covalent WRN helicase inhibitor, with pIC50 (0 h/4 h) = 5.4/7.5 in the DNA-unwinding 5 endpoint assays. WRN-IN-19 shows synthetic lethality in MSI-H (high microsatellite instability) cancer cells[1].
CAS Number
3058652-58-4
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(N1C[C@@H](C(N2CC3(CCC3)C2)=O)N(C(C=C)=O)CC1)CC4=CC=C(C(F)(F)F)C=C4
Molecular Formula
C23H26F3N3O3
Molecular Weight
449.47
References & Citations
[1]Sam M. Rowe, et al. ‘Direct-to-biology’ drives optimisation of a cell-active covalent inhibitor of WRN helicase
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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