TRPM4-IN-2

• Product Name Alternative:

  NBA

• UNSPSC Description:

  TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer[1][2].

• Target Antigen:

  TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/trpm4-in-2.html

• Purity:

  99.21

• Solubility:

  DMSO : 100 mg/mL (ultrasonic;warming)

• Smiles:

  O=C(O)C1=CC=C(Cl)C=C1NC(COC2=C3C=CC=CC3=CC=C2)=O

• Molecular Weight:

  355.77

• References & Citations:

  [1]Borgström A, et al. Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. J Mol Biol. 2021 Aug 20;433(17):166665.|[2]Stokłosa P, et al. Investigation of Novel Small Molecular TRPM4 Inhibitors in Colorectal Cancer Cells. Cancers (Basel). 2021 Oct 28;13(21):5400.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  667411-04-3