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BACE-1/Mpro-IN-1

CAT: 0804-HY-178374Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178374Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BACE-1/Mpro-IN-1 is a high brain-penetrant BACE-1 (IC50 = 0.26 μM) and SARS-CoV-2 Mpro (IC50 = 0.91 μM) dual inhibitor. BACE-1/Mpro-IN-1 binds to the aspartyl protease and cysteine protease as a mixed-type inhibitor. BACE-1/Mpro-IN-1 exhibits the most favorable docking score and a strong interaction profile. BACE-1/Mpro-IN-1 can be used for the study of COVID-19 exacerbated Neuroinflammation and Alzheimer’s disease[1].
UNSPSC
12352005
Target
Beta-secretase; SARS-CoV
Related Pathways
Anti-infection; Neuronal Signaling
Field of Research
Infection; Neurological Disease
Smiles
COC1=CC=C(C=C1)NC(C2=CC(C3=CC=CC=C3)=NC4=CC=C(C=C42)C5=CC=NC=C5)=O
Molecular Formula
C28H21N3O2
Molecular Weight
431.49
References & Citations
[1]Khan AH, et al. Mitigating SARS-CoV-2-exacerbated neuroinflammation and Alzheimer's pathology: Synthesis of quinoline-based dual inhibitors targeting cysteine and aspartyl proteases. Eur J Med Chem. 2025 Dec 15;300:118144.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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