BACE-IN-1

• Description :

  BACE-IN-1 (Compound 13) is a substituted lmidazo[1 ,2-a]pyridine derivative which can inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease.

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H335

• Target :

  Beta-secretase

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Imidazo[1,2-a]pyridine-2-carboxamide,_6-chloro-N-[6-_phenylmethoxy_-1H-benzimidazol-2-yl]-.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=CN2C=C(Cl)C=CC2=N1)NC3=NC4=CC=C(OCC5=CC=CC=C5)C=C4N3

• Molecular Formula :

  C22H16ClN5O2

• Molecular Weight :

  417.85

• Precautions :

  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

• References & Citations :

  [1]Adnan M.M. Mjalli, et al. SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS β-SECRETASE INHIBITORS. WO 2010126745 A1

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1254166-60-3]