BACE-IN-1

• UNSPSC Description:

  BACE-IN-1 (Compound 13) is a substituted lmidazo[1 ,2-a]pyridine derivative which can inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease.

• Target Antigen:

  Beta-secretase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Imidazo[1,2-a]pyridine-2-carboxamide,_6-chloro-N-[6-_phenylmethoxy_-1H-benzimidazol-2-yl]-.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CN2C=C(Cl)C=CC2=N1)NC3=NC4=CC=C(OCC5=CC=CC=C5)C=C4N3

• Molecular Weight:

  417.85

• References & Citations:

  [1]Adnan M.M. Mjalli, et al. SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS β-SECRETASE INHIBITORS. WO 2010126745 A1

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1254166-60-3