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VHR-IN-9

CAT: 0804-HY-178301Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178301Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VHR-IN-9 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 270 nM. VHR-IN-9 shows very weaker inhibitory activity against MKP-1 (IC50 = 2.8 μM), CD45 (IC50 = 1.8 μM), Cdc25A (IC50 = > 10 μM), PTP1B (IC50 = 2.2 μM), and HePTP (IC50 = 2.4 μM) . VHR-IN-9 inhibits the proliferation of HeLa cells. VHR-IN-9 can be used for the research of cervical cancer[1].
CAS Number
1146616-18-3
UNSPSC
12352005
Target
Phosphatase
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=S(C(C=C1)=CC=C1C2=NN(C3=CC=CC=C3)C=C2/C=C4C(N(C(S/4)=S)CCS(=O)(O)=O)=O)(N5CCCCC5)=O
Molecular Formula
C26H26N4O6S4
Molecular Weight
618.77
References & Citations
[1]Wu S, et al. Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells. J Med Chem. 2009 Nov 12;52 (21) :6716-23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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