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VHR-IN-5

CAT: 0804-HY-178295Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178295Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VHR-IN-5 is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 78 nM. VHR-IN-5 shows very weaker inhibitory activity against MKP-1 (IC50 = 0.78 μM), CD45 (IC50 = 0.61 μM), Cdc25A (IC50 = 3.4 μM), PTP1B (IC50 = 1.8 μM), and HePTP (IC50 = 1.5 μM) . VHR-IN-5 inhibits the proliferation of HeLa cells. VHR-IN-5 can be used for the research of cervical cancer[1].
CAS Number
956442-05-0
UNSPSC
12352005
Target
Phosphatase
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(N(C(S/1)=S)CCS(=O)(O)=O)C1=C\C2=CN(C3=CC=CC=C3)N=C2C4=CC=C(C=C4)OCC5=CC=CC=C5
Molecular Formula
C28H23N3O5S3
Molecular Weight
577.69
References & Citations
[1]Wu S, et al. Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells. J Med Chem. 2009 Nov 12;52 (21) :6716-23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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