CSBP ligand 1

CAT: 0804-HY-178214Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-178214Size:1 Each
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Description
CSBP ligand 1 (Compound 36) is a ligand of CSBP, with an IC50 of 0.08 μM for CSBP binding. CSBP ligand 1 can inhibit the production of TNF in mice treated with LPS (HY-D1056) . CSBP ligand 1 has no significant inhibitory activity against PGHS-1 (IC50: 16 μM) and 5-LO (IC50: 60 μM) . CSBP ligand 1 can be used in the research of inflammation-related diseases[1].
CAS Number
[165806-32-6]
UNSPSC
12352005
Target
Lipoxygenase; Ser/Thr Kinase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
FC1=CC=C(C2=C(C3=CC=NC=C3)N(C4CC4)C=N2)C=C1
Molecular Formula
C17H14FN3
Molecular Weight
279.31
References & Citations
[1]Boehm JC, et al. 1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency. J Med Chem. 1996 Sep 27;39 (20) :3929-37.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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