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KRASG12C ligand-1

CAT: 0804-HY-173252Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173252Size:1 Each
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Description
KRASG12C ligand-1 is a PROTAC target protein ligand that can be used to synthesize the PROTAC YN14-H. YN14-H is a PROTAC degrader targeting KRASG12C and has antitumor activity[1].
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1N(C2=C(C)C=CN=C2C(C)C)C3=NC(C4=C(C=CC=C4OCC5CCNCC5)F)=C(F)C=C3C(N6[C@@H](C)CN(C(C=C)=O)CC6)=N1
Molecular Formula
C36H41F2N7O3
Molecular Weight
657.75
References & Citations
[1]Sun S, et al. Rational design of VHL-recruiting KRASG12C proteolysis-targeting chimeras based on molecular dynamics simulation. Chinese Chemical Letters, 2025: 110992.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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