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AHR agonist 10

CAT: 0804-HY-178053Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178053Size:1 Each
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Description
AHR agonist 10 is a potent AHR agonist (EC50 = 2.01 nM) . AHR agonist 10 can elevate the transcript levels of key AHR downstream pathway target genes, including CYP1A1 and CYP1B1. AHR agonist 10 can downregulate the expression levels of CD36, IL-18 and shows low cytotoxicity (>40 μM) to normal cells. AHR agonist 10 can suppress the expression of CCL5, CCL20, IL-6, IL-8, S100A9, TLR4, TNF-α, and TNFR1, demonstrating that AHR agonist 10 effectively modulate inflammatory responses through AHR dependent signaling pathways. AHR agonist 10 can be used for psoriasis research[1].
CAS Number
1191937-43-5
UNSPSC
12352005
Target
Aryl Hydrocarbon Receptor; Cytochrome P450; Interleukin Related
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CC(C1=C(C=C(C=C1O)/C=C/C2=CC=C(C=C2)OC)O)C
Molecular Formula
C18H20O3
Molecular Weight
284.35
References & Citations
[1]Zhao Y, et al. Design, Optimization, and Biological Evaluation of Novel Tapinarof Analogues as AHR Agonists for Topical Psoriasis Treatment. J Med Chem. 2025 Sep 25;68 (18) :19249-19268.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6; IL-8

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