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AhR agonist 2

CAT: 0804-HY-144339-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-144339-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AhR agonist 2 (Compound 12a) is a potent agonist of aryl hydrocarbon receptor (AhR) with an EC50 of 0.03 nM. AhR agonist 2 induces rapid nuclear enrichment of AhR, triggers the transcription of downstream genes and promote skin barrier repair. AhR agonist 2 has the potential for the research of psoriasis[1].
CAS Number
2975270-19-8
UNSPSC
12352005
Target
Aryl Hydrocarbon Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ahr-agonist-2.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 70°C)
Smiles
BrC1=CC=C(C=C1)C2=NN3C=C(C=CC3=N2)Br
Molecular Formula
C12H7Br2N3
Molecular Weight
353.01
References & Citations
[1]Tian C, et al. Identification of triazolopyridine derivatives as a new class of AhR agonists and evaluation of anti-psoriasis effect in a mouse model. Eur J Med Chem. 2022;231:114122.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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