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VEGFR-2-IN-71

CAT: 0804-HY-175018Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175018Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VEGFR-2-IN-71 is a dual VEGFR2/tubulin inhibitor. VEGFR-2-IN-71 inhibits tumor cell proliferation and induces apoptosis and cell cycle arrest. VEGFR-2-IN-71 inhibits angiogenesis in the chick chorioallantoic membrane (CAM) model. VEGFR-2-IN-71 inhibits tumor growth in the HGC-27 xenograft model by inhibiting VEGFR2 and tubulin. VEGFR-2-IN-71 has low oral bioavailability in rats. VEGFR-2-IN-71 can be used in cancer research[1].
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin; VEGFR
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Cardiovascular Disease
Smiles
COC1=C(OC)C(OC)=C(C(C=C(C2=CC=C(NC(NC3=CC=C(F)C(C(F)(F)F)=C3)=O)C=C2)O4)=O)C4=C1
Molecular Formula
C26H20F4N2O6
Molecular Weight
532.44
References & Citations
[1]He X, et al. Discovery of novel flavonoid derivatives targeting VEGFR2 and tubulin with potent anticancer efficacy. Bioorg Chem. 2025 Jun 30;163:108713.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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