Pro-PTX

• Description :

  Pro-PTX is an inactive prodrug of Paclitaxel (HY-B0015) . Pro-PTX does not show cytotoxicity against cancer cells, such as A549, U87 and HBVP cells. Pro-PTX can be converted into Paclitaxel through dealkylation catalyzed by Pd nanosheets in agarose and alginate hydrogels[1].

• UNSPSC :

  12352005

• Target :

  Drug Intermediate

• Related Pathways :

  Others

• Field of Research :

  Others

• Smiles :

  CC1=C([C@@H](OC(C)=O)C([C@@]2(C)[C@]([C@@](CO3)(OC(C)=O)[C@@]3([H])C[C@@H]2O)([H])[C@@H]4OC(C5=CC=CC=C5)=O)=O)C(C)(C)[C@@]4(O)C[C@@H]1OC([C@H](OC(N(CCN(C(OCC#C)=O)C)C)=O)[C@@H](NC(C6=CC=CC=C6)=O)C7=CC=CC=C7)=O

• Molecular Formula :

  C56H63N3O17

• Molecular Weight :

  1050.11

• References & Citations :

  [1]Pérez-López AM, et al. Bioorthogonal Uncaging of Cytotoxic Paclitaxel through Pd Nanosheet-Hydrogel Frameworks. J Med Chem. 2020 Sep 10;63 (17) :9650-9659.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3011748-20-9]