IR820-PTX

• Description :

  IR820-PTX, an IR-820 (HY-136886) -Paclitaxel (HY-B0015) conjugate, is an amphipathic small molecule prodrug. IR820-PTX effectively inhibits tumor growth via combined photothermal therapy (PTT) and chemotherapy[1][2].

• UNSPSC :

  12171500

• Target :

  Fluorescent Dye; Microtubule/Tubulin

• Type :

  Dye Reagents

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton; Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ir820-ptx.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(O[C@]12[C@@]3([H])[C@@H]([C@]4(C(C)(C([C@H](C([C@@]3([C@H](C[C@@]1([H])OC2)O)C)=O)OC(C)=O)=C([C@H](C4)OC([C@H](OC(CCCCCNC5=C(/C=C/C6=[N+](C7=C(C8=CC=CC=C8C=C7)C6(C)C)CCCCS(=O)(O[Na])=O)CCC/C5=C\C=C9N(C%10=C(C%11=CC=CC=C%11C=C%10)C\9(C)C)CCCCS(=O)(O)=O)=O)[C@H](C%12=CC=CC=C%12)NC(C%13=CC=CC=C%13)=O)=O)C)C)O)OC(C%14=CC=CC=C%14)=O)=O

• Molecular Formula :

  C99H112N4NaO21S2+

• Molecular Weight :

  1781.08

• References & Citations :

  [1]Zhang D, et al. pH- and Enzyme-Sensitive IR820-Paclitaxel Conjugate Self-Assembled Nanovehicles for Near-Infrared Fluorescence Imaging-Guided Chemo-Photothermal Therapy. ACS Appl Mater Interfaces. 2018 Sep 12;10 (36) :30092-30102.|[2]Yu-Xia Luan, et al. Preparation method and application of amphiphilic small molecule prodrug of ir820-ptx combined with photothermal therapy and chemotherapy and its nanoparticles. CN108727353B.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Dye Reagents

• Clinical Information :

  No Development Reported

• CAS Number :

  [2250419-19-1]