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Estrogen receptor modulator 8

CAT: 0804-HY-153700Size: 1 EachDry Ice: NoHazardous: No
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Description
Estrogen receptor modulator 8 (Compound 4) down-regulates estrogen receptor with an IC50 of 0.1 nM-10 nM. Estrogen receptor modulator 8 degrades ERα (IC50: 25.7 nM in vitro, 0.136 nM in MCF-7 cell) . Estrogen receptor modulator 8 also inhibits MCF-7 cell growth (IC50: 0.1 nM), and MCF-7 tumor growth[1].
CAS Number
2170766-56-8
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/estrogen-receptor-modulator-8.html
Solubility
10 mM in DMSO
Smiles
CC(C)(F)CN1[C@H](C2=C(C=C(C=C2F)/C=C/C(O)=O)F)C3=C(C[C@H]1C)C4=C(F)C=CC=C4N3
Molecular Formula
C25H24F4N2O2
Molecular Weight
460.46
References & Citations
[1]Guan D, et al. Preparation of 3-[4- (tetrahydro-1H-pyrrolo[3,4-b]indol-1-yl) phenyl]acrylic acid compound useful as estrogen receptor down-regulator (SERD) . World Intellectual Property Organization, WO2018001232 A1. 2018-01-04.|[2]Guan, dongliang. Acrylic acid derivative, preparation method thereof and application thereof in medicine. Patent. CN109415361.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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