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NVP-QBE170

CAT: 0804-HY-177311Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-177311Size:1 Each
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Description
NVP-QBE170 is a selective Epithelial sodium channel (ENaC) inhibitor with an IC50 of 57.5 nM. NVP-QBE170 potently inhibits ENaC function in HBECs and shows a longer duration of action. NVP-QBE170 significantly attenuates ENaC activity in the airways of guinea pig models. NVP-QBE170 can be used for hyperkalaemia research[1].
CAS Number
1080018-61-6
UNSPSC
12352100
Target
Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Metabolic Disease
Smiles
O=C(C1=NC(Cl)=C(N)N=C1N)NC(NC2CCN(CC2)C(C3=CC=C(C(N4CCC(CC4)NC(NC(C5=NC(Cl)=C(N)N=C5N)=O)=N)=O)C=C3)=O)=N
Molecular Formula
C30H36Cl2N16O4
Molecular Weight
755.62
References & Citations
[1]Coote KJ, et al. NVP-QBE170: an inhaled blocker of the epithelial sodium channel with a reduced potential to induce hyperkalaemia. Br J Pharmacol. 2015 Jun;172 (11) :2814-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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