RSC-1255

• Description :

  RSC-1255 is a potent and selective Vacuolar H⁺-ATPase (V-ATPase) inhibitor that directly binds the mammalian V-ATPase complex with a Kd = 23 nM. RSC-1255 exhibits preferential cytotoxicity toward KRAS-mutant cancer cells, especially KRASG13D and KRASG12V cells. RSC-1255 blocks lysosomal acidification, autophagy, and macropinocytosis in cancer cells. RSC-1255 can be used for the study of KRAS-driven lung and colon cancers[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Autophagy; Proton Pump; Ras

• Related Pathways :

  Apoptosis; Autophagy; GPCR/G Protein; MAPK/ERK Pathway; Membrane Transporter/Ion Channel

• Field of Research :

  Cancer

• Smiles :

  O=C(C1(C)N(C2=CC=C(C=C2F)F)N=C(C1C3=CC=C(Cl)O3)C4=C(F)C=C(F)C=C4)NCC5OCCN(C5)C

• Molecular Formula :

  C27H25ClF4N4O3

• Molecular Weight :

  564.96

• References & Citations :

  [1]Tolani B, et al. Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice. Nat Biotechnol. 2022;40 (12) :1834-1844.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  K-Ras

• CAS Number :

  [2171015-78-2]