RegisterLogin

MK 1256

CAT: 0804-HY-14360Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-14360Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
MK 1256 is a highly selective and orally active inhibitor of tissue protease K (Cat K) with an IC50 of 0.62 nM. MK 1256 shows extremely high selectivity towards other tissue proteases (all > 1100 times), with only a slightly lower selectivity for tissue protease F (Cat F) (110 times) . MK 1256 exhibits strong anti-bone resorption activity in the osteoporosis model of rhesus monkeys with ovariectomy. MK 1256 can be used for research on osteoporosis[1].
CAS Number
[919109-76-5]
UNSPSC
12352005
Target
Cathepsin
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O=C([C@H]1[C@H](C2=NN(CC(F)(F)F)C=C2C3=CC=C(S(=O)(C)=O)C=C3)CCC(Cl)(Cl)C1)NC4(C#N)CC4
Molecular Formula
C23H23Cl2F3N4O3S
Molecular Weight
563.42
References & Citations
[1]Robichaud J, et al. Identification of a nonbasic, nitrile-containing cathepsin K inhibitor (MK-1256) that is efficacious in a monkey model of osteoporosis. J Med Chem. 2008 Oct 23;51 (20) :6410-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-RI00160A-01Hsa-miR-1256 antagomir
HY-R00160A-01Hsa-miR-1256 agomir
HY-R00160-01Hsa-miR-1256 mimic
HY-RI00160-01Hsa-miR-1256 inhibitor
HY-112319MK-8457
HY-11072MK-0359
HY-108232-01MK-2206
HY-101324MK-212
HY-14166-01MK-886
HY-10413-01MK-2894

Alternative Products

CatalogName
MPH01075hsa-miR-1256 Primers
35-477Parainfluenza Virus Antibody [1256]
MBS8316724-01hsa-miR-1256 miRNA Antagomir
MBS8293582-01hsa-miR-1256 miRNA Inhibitor
MBS8311477-01hsa-miR-1256 miRNA Agomir
12-8354-1.0Anti-Clozapine- (Clone CLO-1256)
sc-58177Parainfluenza Virus type 3 (1256)
mh40083LentimiRa-hsa-mir-1256 Vector
MBS8298829-01hsa-miR-1256 miRNA Mimic
abx880782-01Human hsa-miR-1256 miRNA Agomir

Popular Products