S-1255

• Description :

  S-1255 is an orally active and highly selective endothelin ETA receptor antagonist (Kd=0.39 nM) . S-1255 blocks vasoconstriction and sustains hypotensive effects in hypertensive rats. S-1255 is promising for research of hypertension and cardiovascular disorders[1].

• UNSPSC :

  12352005

• Target :

  Endothelin Receptor

• Related Pathways :

  GPCR/G Protein

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Smiles :

  OC(C1=C(C2=CC=C(C=C2)OC)C3=CC(OC(C)C)=CC=C3O[C@@H]1C4=CC=C(OCO5)C5=C4)=O

• Molecular Formula :

  C27H24O7

• Molecular Weight :

  460.48

• References & Citations :

  [1]Iwasaki T, et al. Pharmacologic characterization of S-1255, a highly potent and orally active endothelin A receptor antagonist. J Cardiovasc Pharmacol. 2001 Apr;37 (4) :471-82.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ETA

• CAS Number :

  [203918-14-3]