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Rodin-C

CAT: 0804-HY-176868Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176868Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rodin-C is a selective HDAC inhibitor with IC50s of 0.059, 0.18 and 5.39 μM for HDAC1, HDAC2 and HDAC11, respectively, over HDAC3-10. Rodin-C significantly inhibits the HDAC-CoREST complex with low hematological toxicity. Rodin-C can be used for neurologic disorders such as Alzheimer’s disease research[1].
CAS Number
2065162-16-3
UNSPSC
12352005
Target
HDAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(N1CC2=NN(C)C=C2C1)NC3=NC(C4=CC=C(F)C=C4)=CC=C3N
Molecular Formula
C18H17FN6O
Molecular Weight
352.37
References & Citations
[1]Fuller NO, et al. CoREST Complex-Selective Histone Deacetylase Inhibitors Show Prosynaptic Effects and an Improved Safety Profile To Enable Treatment of Synaptopathies. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1729-1743.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9

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