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Rodin-A

CAT: 0804-HY-176866Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176866Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rodin-A is an orally active, brain-penetrant and selective histone deacetylase (HDAC) -co-repressor of repressor element-1 silencing transcription factor (CoREST) complex inhibitor with an IC50 value of 1.80 μM for the CoREST complex, 0.15 μM for HDAC1, and 0.43 μM for HDAC2. Rodin-A increases the acetylation level of histone H3K9, upregulates the expression of neuron-related genes, thereby promoting the increase in dendritic spine density, the colocalization of synaptic proteins (SV2A and PSD95), and the improvement of hippocampal long-term potentiation (LTP), exerting synaptic protection and repair activity. Rodin-A is promising for research of neurodegenerative diseases related to synaptic dysfunction, especially Alzheimer’s disease[1].
CAS Number
2222756-46-7
UNSPSC
12352005
Target
HDAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(N1CC2=NC(C)=NC=C2C1)NC3=NC(C4=CC=CS4)=CC=C3N
Molecular Formula
C17H16N6OS
Molecular Weight
352.41
References & Citations
[1]Fuller NO, et al. CoREST Complex-Selective Histone Deacetylase Inhibitors Show Prosynaptic Effects and an Improved Safety Profile To Enable Treatment of Synaptopathies. ACS Chem Neurosci. 2019 Mar 20;10 (3) :1729-1743.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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