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Rodin-B

CAT: 0013-GTR19273674-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273674-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rodin-B is an orally active, brain-penetrant, and selective inhibitor of the histone deacetylase (HDAC) -suppressor of transcription factor corepressor element-1 silencing transcription factor (CoREST) complex. It exhibits an IC50 value of 0.50 μM for the CoREST complex, 0.27 μM for HDAC1, and 0.28 μM for HDAC2. Rodin-B enhances the acetylation level of histone H3K9 and upregulates neuron-related gene expression, promoting increased dendritic spine density, colocalization of synaptic proteins (SV2A and PSD95), and improved hippocampal long-term potentiation (LTP), thereby exerting synaptic protection and repair effects. Rodin-B holds potential for research into neurodegenerative diseases related to synaptic dysfunction, particularly Alzheimer's disease.
Storage Conditions
-20°C
Notes
For research use only.

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