Products for Research Use Only
RegisterLogin

(R) -ACBI-4

CAT: 0804-HY-176792ASize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-176792ASize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
(R) -ACBI-4 is an isomer of ACBI-4. ACBI-4 is a selective GTP-loaded active state of KRAS (KRAS (on) ) PROTAC degrader. ACBI-4 has significant anti-proliferative effect and potently degrades multiple KRAS mutants in cancer cells, such as KRASG12R[1].
CAS Number
3097973-97-9
UNSPSC
12352005
Target
Drug Isomer; PROTACs; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Others; PROTAC
Field of Research
Cancer
Smiles
CC([C@H](N1N=NC2=C1CC[C@@H](CCCN3C[C@@H](N(CCC3)C4=NC(C5=NOC([C@@]6(C7=C(CCC6)SC(N)=C7C#N)C)=N5)=CC=N4)C)C2)C(N8C[C@@H](C[C@H]8C(NCC9=CC=C%10C(N(N=C%10)C)=C9)=O)O)=O)C
Molecular Formula
C50H63N15O4S
Molecular Weight
970.20
References & Citations
[1]Vetma V, et al. Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-loaded KRAS (on) Alleles[J]. 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras; von Hippel-Lindau (VHL)

Related Products

CatalogName
HY-176792-01ACBI-4
HY-170362A-01(R) -cGAS-IN-4
HY-N9746-01(R) -4-Methoxydalbergione
HY-W190740-01DPEG (R) 4-SATA
HY-114395A-01(R) -NVS-ZP7-4
HY-145397A(R) - (4-NH2) -Exatecan
HY-107519(R) -3,4-DCPG
HY-156830A-01(4′R) -TGR5 Receptor Agonist 4
HY-141692B-01(R) -IL-17 modulator 4
HY-W007664-01(R) -4-Benzyl-2-oxazolidinone

Alternative Products

CatalogName
T212494-01ACBI-4
GTR19276122-01(R) -ACBI-4
JH917590ACBI-1
IRBAHUNDC80ACBI14C100ULRabbit Anti Human NDC80 Monoclonal Clone ACBI-14 100UL
IRBAHUNDC80ACBI14C100ugRabbit Anti Human NDC80 Monoclonal Clone ACBI-14 100ug
PC52154,4,4,4',4',4'-Hexafluorovaline hydrochloride
PC64124,4,4-Trifluorobutyl 4,4,4-trifluorobutanoate
OR1011273-014,4',4'',4'''-Methanetetrayltetrabenzaldehyde
OR1011238-014,4,4,4-Silanetetrayltetrabenzaldehyde
OR1011275-014,4',4'',4'''-Methanetetrayltetraphenol

Popular Products