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ACBI-4

CAT: 0804-HY-176792-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-176792-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ACBI-4 is a selective GTP-loaded active state of KRAS (KRAS (on) ) PROTAC degrader. ACBI-4 has significant anti-proliferative effect and potently degrades multiple KRAS mutants in cancer cells, such as KRASG12R[1].
CAS Number
3097985-19-5
UNSPSC
12352005
Target
PROTACs; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
97.97
Smiles
CC([C@H](N1N=NC2=C1CC[C@H](CCCN3C[C@@H](N(CCC3)C4=NC(C5=NOC([C@@]6(C7=C(CCC6)SC(N)=C7C#N)C)=N5)=CC=N4)C)C2)C(N8C[C@@H](C[C@H]8C(NCC9=CC=C%10C(N(N=C%10)C)=C9)=O)O)=O)C
Molecular Formula
C50H63N15O4S
Molecular Weight
970.20
References & Citations
[1]Vetma V, et al. Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-loaded KRAS (on) Alleles[J]. 2025.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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