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(R) -ACBI-4

CAT: 0013-GTR19276122-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19276122-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -ACBI-4 is an isomer of ACBI-4. ACBI-4 acts as a selective PROTAC degrader targeting the GTP-loaded active state of KRAS (KRAS (on) ) . It exhibits significant antiproliferative effects and effectively degrades various KRAS mutants, such as KRASG12R, in cancer cells.
CAS Number
3097973-97-9
Smiles
C[C@]1 (C2=C (SC (N) =C2C#N) CCC1) C3=NC (=NO3) C4=NC (=NC=C4) N5[C@@H] (C) CN (CCC[C@H]6CC7=C (CC6) N ([C@H] (C (=O) N8[C@H] (C (NCC=9C=C%10C (=CC9) C=NN%10C) =O) C[C@@H] (O) C8) [C@H] (C) C) N=N7) CCC5
Molecular Formula
C50H63N15O4S
Molecular Weight
970.22
Storage Conditions
-20°C
Notes
For research use only.

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