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MSK-9

CAT: 0804-HY-176731Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176731Size:1 Each
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Description
MSK-9 is a positive allosteric modulator of the P2X4 receptor with dual activities of enhancing ion conductance and delaying receptor inactivation. MSK-9 stabilizes the open state of the P2X4 receptor through rigid 3-piperidinyl and hydrophobic menthyl substituents. MSK-9 can be used in the study of multiple sclerosis (MS) [1].
UNSPSC
12352005
Target
P2X Receptor
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Smiles
CC(C)[C@H]1CC[C@@H](C)C[C@H]1N2N=NC(C3=CC(C4=CN(N=N4)[C@H]5CNCCC5)=CC(C6=CN(N=N6)[C@@H]7CCCNC7)=C3)=C2
Molecular Formula
C32H45N11
Molecular Weight
583.77
References & Citations
[1]Mata P, et al. Positive allosteric modulators of purinergic P2X4 receptors: design, synthesis and therapeutic potential of "click" ligands for multiple sclerosis. Eur J Med Chem. 2025 Jun 12;296:117862.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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