MSK-9

• Description :

  MSK-9 is a positive allosteric modulator of the P2X4 receptor with dual activities of enhancing ion conductance and delaying receptor inactivation. MSK-9 stabilizes the open state of the P2X4 receptor through rigid 3-piperidinyl and hydrophobic menthyl substituents. MSK-9 can be used in the study of multiple sclerosis (MS) [1].

• UNSPSC :

  12352005

• Target :

  P2X Receptor

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Neurological Disease

• Smiles :

  CC(C)[C@H]1CC[C@@H](C)C[C@H]1N2N=NC(C3=CC(C4=CN(N=N4)[C@H]5CNCCC5)=CC(C6=CN(N=N6)[C@@H]7CCCNC7)=C3)=C2

• Molecular Formula :

  C32H45N11

• Molecular Weight :

  583.77

• References & Citations :

  [1]Mata P, et al. Positive allosteric modulators of purinergic P2X4 receptors: design, synthesis and therapeutic potential of "click" ligands for multiple sclerosis. Eur J Med Chem. 2025 Jun 12;296:117862.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported