ST-899

• Description :

  ST-899 is a novel platelet-activating factor (PAF) receptor antagonist. ST-899 can significantly reduce the mortality of mice with endotoxin (LPS) -induced shock. ST-899 can significantly inhibit the increase in serum tumor necrosis factor (TNF) levels induced by LPS, but has no effect on interleukin-6 (IL-6) . The regulatory mechanism of ST-899 is to block the positive feedback loop between PAF and TNF, thereby reducing the inflammatory response. ST-899 can be used to study inflammatory diseases such as septic shock[1].

• CAS Number :

  [143484-41-7]

• UNSPSC :

  12352005

• Target :

  Platelet-activating Factor Receptor (PAFR) ; TNF Receptor

• Related Pathways :

  Apoptosis; GPCR/G Protein

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C(O/1)C2=CC=C(Cl)C=C2C1=C\COC(C[C@@H](OC(CC(C)C)=O)C[N+](C)(C)C)=O.[Br-]

• Molecular Formula :

  C22H29BrClNO6

• Molecular Weight :

  518.83

• References & Citations :

  [1]Ruggiero V, et al. Beneficial effects of a novel platelet-activating factor receptor antagonist, ST 899, on endotoxin-induced shock in mice. Shock. 1994 Oct;2 (4) :275-80.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported