ST-899

CAT: 0804-HY-176466Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-176466Size:1 Each
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Description
ST-899 is a novel platelet-activating factor (PAF) receptor antagonist. ST-899 can significantly reduce the mortality of mice with endotoxin (LPS) -induced shock. ST-899 can significantly inhibit the increase in serum tumor necrosis factor (TNF) levels induced by LPS, but has no effect on interleukin-6 (IL-6) . The regulatory mechanism of ST-899 is to block the positive feedback loop between PAF and TNF, thereby reducing the inflammatory response. ST-899 can be used to study inflammatory diseases such as septic shock[1].
CAS Number
[143484-41-7]
UNSPSC
12352005
Target
Platelet-activating Factor Receptor (PAFR) ; TNF Receptor
Related Pathways
Apoptosis; GPCR/G Protein
Field of Research
Inflammation/Immunology
Smiles
O=C(O/1)C2=CC=C(Cl)C=C2C1=C\COC(C[C@@H](OC(CC(C)C)=O)C[N+](C)(C)C)=O.[Br-]
Molecular Formula
C22H29BrClNO6
Molecular Weight
518.83
References & Citations
[1]Ruggiero V, et al. Beneficial effects of a novel platelet-activating factor receptor antagonist, ST 899, on endotoxin-induced shock in mice. Shock. 1994 Oct;2 (4) :275-80.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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