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ST-899

CAT: 0013-GTR19263879-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263879-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ST-899 is an innovative platelet-activating factor (PAF) receptor antagonist. It significantly reduces the mortality rate in mice experiencing shock induced by endotoxins (LPS) . The compound markedly inhibits the LPS-induced increase in serum tumor necrosis factor (TNF) levels while leaving interleukin-6 (IL-6) unaffected. The mechanism by which ST-899 operates involves disrupting the positive feedback loop between PAF and TNF, thereby mitigating inflammatory responses. ST-899 is applicable for studies related to inflammatory diseases such as septic shock.
CAS Number
143484-41-7
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Smiles
C (\COC (C[C@@H] (OC (CC (C) C) =O) C[N+] (C) (C) C) =O) =C\1/C=2C (C (=O) O1) =CC=C (Cl) C2.[Br-]
Molecular Formula
C22H29BrClNO6
Molecular Weight
518.83
Storage Conditions
-20°C
Notes
For research use only.

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