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ST-899

CAT: 0013-GTR19263879-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263879-01Size:50 mg
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Description
ST-899 is an innovative platelet-activating factor (PAF) receptor antagonist. It significantly reduces the mortality rate in mice experiencing shock induced by endotoxins (LPS) . The compound markedly inhibits the LPS-induced increase in serum tumor necrosis factor (TNF) levels while leaving interleukin-6 (IL-6) unaffected. The mechanism by which ST-899 operates involves disrupting the positive feedback loop between PAF and TNF, thereby mitigating inflammatory responses. ST-899 is applicable for studies related to inflammatory diseases such as septic shock.
CAS Number
143484-41-7
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Smiles
C (\COC (C[C@@H] (OC (CC (C) C) =O) C[N+] (C) (C) C) =O) =C\1/C=2C (C (=O) O1) =CC=C (Cl) C2.[Br-]
Molecular Formula
C22H29BrClNO6
Molecular Weight
518.83
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

ST 899

a platelet-activating factor receptor antagonist

CAS Number143484-41-7
PubChem CID6442326
IUPAC Name[(2R)-4-[(2Z)-2-(6-chloro-3-oxo-2-benzofuran-1-ylidene)ethoxy]-2-(3-methylbutanoyloxy)-4-oxobutyl]-trimethylazanium bromide
Molecular FormulaC22H29BrClNO6
Molecular Weight518.8
Topological Polar Surface Area78.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count11
Heavy Atom Count31
Formal Charge0
Complexity669
SMILES
CC(C)CC(=O)O[C@H](CC(=O)OC/C=C\1/C2=C(C=CC(=C2)Cl)C(=O)O1)C[N+](C)(C)C.[Br-]
InChI
InChI=1S/C22H29ClNO6.BrH/c1-14(2)10-21(26)29-16(13-24(3,4)5)12-20(25)28-9-8-19-18-11-15(23)6-7-17(18)22(27)30-19;/h6-8,11,14,16H,9-10,12-13H2,1-5H3;1H/q+1;/p-1/b19-8-;/t16-;/m1./s1
InChIKey
PHQDKXWPTYPXJJ-XDCMQMGXSA-M
Chemical Structure
2D Structure
2D structure of ST 899
CAS: 143484-41-7
CID: 6442326
Formula: C22H29BrClNO6
MW: 518.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight518.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count11
Exact Mass517.08668
Monoisotopic Mass517.08668
Topological Polar Surface Area78.9 Ų
Heavy Atom Count31
Formal Charge0
Complexity669
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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