CES2A-IN-3

• Description:

  CES2A-IN-3 (Compound 9d) is a potent serine-targeting covalent human carboxylesterase 2A (hCES2A) inhibitor with an IC50 value of 0.12 nM. CES2A-IN-3 is promising for research of diarrhea and ulcerative colitis[1].

• UNSPSC:

  12352005

• Target:

  Carboxylesterase (CES)

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  CCCCCCCCC(C1=C2C=C(OC2=CC=C1)C3=CC(OC)=CC=C3OC(N4CCCC4)=O)=O

• Molecular Formula:

  C29H35NO5

• Molecular Weight:

  477.59

• References & Citations:

  [1]Hu D, et al. Discovery of a Novel Serine-Targeting Covalent Inhibitor against HCES2A for Treating Drug-induced Diarrhea and Ulcerative Colitis. J Med Chem. 2025 May 21.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CES2

• CAS Number:

  [3037959-47-7]