CES2A-IN-3

• Description :

  CES2A-IN-3 (Compound 9d) is a potent serine-targeting covalent human carboxylesterase 2A (hCES2A) inhibitor with an IC50 value of 0.12 nM. CES2A-IN-3 is promising for research of diarrhea and ulcerative colitis[1].

• UNSPSC :

  12352005

• Target :

  Carboxylesterase (CES)

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Smiles :

  CCCCCCCCC(C1=C2C=C(OC2=CC=C1)C3=CC(OC)=CC=C3OC(N4CCCC4)=O)=O

• Molecular Formula :

  C29H35NO5

• Molecular Weight :

  477.59

• References & Citations :

  [1]Hu D, et al. Discovery of a Novel Serine-Targeting Covalent Inhibitor against HCES2A for Treating Drug-induced Diarrhea and Ulcerative Colitis. J Med Chem. 2025 May 21.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CES2

• CAS Number :

  [3037959-47-7]