Products for Research Use Only
RegisterLogin

CDK9 degrader-1

CAT: 0804-HY-176451Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-176451Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CDK9 degrader-1 (Compound AZ-9) is a selective CDK9 degrader (DC50: 0.4073 µM) . CDK9 degrader-1 recruits ATG101 to initiate the autophagy-lysosome pathway and forms autophagosomes by recruiting LC3, which then fuses with lysosomes to degrade CDK9 and its partner protein Cyclin T1 (DC50: 1.215 µM) . CDK9 degrader-1 induces caspase 3-mediated apoptosis. CDK9 degrader-1 has antitumor activity in a mouse HCT116 xenograft model[1].
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
ClC1=C(C(NC2=CNN=C2C(NC3CCN(C(CCC(NC4=C(CCC5)C5=CC6=C4CCC6)=O)=O)CC3)=O)=O)C(Cl)=CC=C1
Molecular Formula
C32H34Cl2N6O4
Molecular Weight
637.56
References & Citations
[1]Zhong Y, et al. First ATG101-recruiting small molecule degrader for selective CDK9 degradation via autophagy–lysosome pathway[J]. Acta Pharmaceutica Sinica B, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9

Related Products

CatalogName
HY-168896CDK9 autophagic degrader 1
HY-170978PROTAC CDK9 degrader-11
HY-168518-01PROTAC CDK9 degrader-9
HY-149963PROTAC CDK9 degrader-6
HY-149964-01PROTAC CDK9 degrader-7
HY-115728-01PROTAC CDK9 degrader-4
HY-112811-01PROTAC CDK9 degrader-2
HY-149962PROTAC CDK9 degrader-5
HY-149870PROTAC CDK9 degrader-8
HY-156795PROTAC CDK9/CycT1 Degrader-2

Alternative Products

CatalogName
T207627-01CDK9 degrader-1
MBS5758225PROTAC CDK9 Degrader-1
GTR19249992-01CDK9 autophagic degrader 1
A20040-5PROTAC CDK9 Degrader-1 5mg
A20040-1PROTAC CDK9 Degrader-1 1mg
MBS5816645PROTAC FLT3/CDK9 degrader-1
A20040-100PROTAC CDK9 Degrader-1 100mg
A20040-50PROTAC CDK9 Degrader-1 50mg
A20040-10PROTAC CDK9 Degrader-1 10mg
A20040-25PROTAC CDK9 Degrader-1 25mg

Popular Products