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Lenalidomide-amide-pimelic acid

CAT: 0804-HY-176430Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176430Size:1 Each
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Description
Lenalidomide-amide-pimelic acid is an E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based CRBN ligand and Linker (HY-Y1139). Lenalidomide-amide-pimelic acid can be used for synthesis of PROTAC MNK1 degrader-1 (HY-176428).
CAS Number
2353496-83-8
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(CCCCCC(O)=O)NC1=CC=CC2=C1CN(C2=O)C3C(NC(CC3)=O)=O
Molecular Formula
C20H23N3O6
Molecular Weight
401.41
References & Citations
[1]Yang Z, et al. Discovery of P11-2: A Potent First-in-Class MNK1-Targeting PROTAC Degrader for the Treatment of Cancer. J Med Chem. 2025 May 22; 68 (10) :10092-10110.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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