Lenalidomide nonanedioic acid

• Description:

  Lenalidomide nonanedioic acid is a conjugate of the E3 ligase ligand and linker of LHF418 (HY-161450) . Lenalidomide nonanedioic acid can be used as a key intermediate for the synthesis of intact PROTACs molecules[1].

• UNSPSC:

  12352005

• Target:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lenalidomide-nonanedioic-acid.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)CCCCCCCC(NC1=C2C(C(N(C3CCC(NC3=O)=O)C2)=O)=CC=C1)=O

• Molecular Formula:

  C22H27N3O6

• Molecular Weight:

  429.47

• References & Citations:

  [1]Li H, et al. Discovery of LHF418 as a new potent SOS1 PROTAC degrader. Bioorg Med Chem. 2024 Apr 1;103:117661. doi: 10.1016/j.bmc.2024.117661. Epub 2024 Mar 2. PMID: 38489998.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported