Hsp90-IN-38

CAT: 0931-T205493-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T205493-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3065556-04-6

Target

HSP, ATPase

Related Pathways

Cytoskeletal Signaling, Membrane transporter/Ion channel, Metabolism

Bioactivity

Hsp90-IN-38 (compound 20m) is an inhibitor of HSP90 (heat shock protein) . It demonstrates a strong binding affinity to HSP90 with a Kd of 87 nM. The compound inhibits ATPase activity with an IC50 of 0.13 μM. Hsp90-IN-38 also shows inhibitory effects on HCT116, MCF-7, SKBr3, K562, and A549 cells with IC50 values of 0.187, 0.072, 0.105, 0.403, and 0.031 μM, respectively.

Smiles

C(=O)(N1[C@@H](C(NCCCN2CCOCC2)=O)C[C@@H](C1)C3=CC=CC=C3)C4=CC(=C(O)C=C4O)C5CC5

Molecular Formula

C28H35N3O5

Molecular Weight

493.595

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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