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Antifibrotic agent 1

CAT: 0804-HY-176194Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176194Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antifibrotic agent 1 is an orally active anti-idiopathic pulmonary fibrosis (IPF) agent. Antifibrotic agent 1 effectively attenuates IPF-related processes, including TGF-β induced EMT and FMT processes, as well as pro-fibrotic M2 polarization. Antifibrotic agent 1 selectively inhibits CSF-1R, PDGFR-α and Src family kinases (SFKs), while sparing VEGFRs, FGFRs and Abl to minimize off-target toxicity. Antifibrotic agent 1 has potent anti-fibrotic activity in Bleomycin (BLM) -induced pulmonary fibrosis mice model[1].
UNSPSC
12352005
Target
C-Fms; Collagen; PDGFR; Src
Related Pathways
Cytoskeleton; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CC(NC1=CC=C(C(Cl)=C1)NC(C2=CC=C(C(C#CC3=CC(C4=CN(N=C4)C)=CN=C3N)=C2)C)=O)=O
Molecular Formula
C27H23ClN6O2
Molecular Weight
498.96
References & Citations
[1]Chen X, et al. Design, synthesis, and biological evaluation of N- (2-amino-phenyl) -5- (4-aryl-pyrimidin-2-yl) amino) -1H-indole-2-carboxamide derivatives as novel inhibitors of CDK9 and class I HDACs for cancer treatment [J]. Bioorganic Chemistry, 2025: 108577.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Collagen I; Fyn; Hck; Lck; Lyn; PDGFRα; Yes

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