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Antifibrotic agent 1

CAT: 0931-T207178-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207178-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
C-Fms, Others, PDGFR, Src
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Others
Bioactivity
Antifibrotic agent 1 is an orally active medication designed to treat idiopathic pulmonary fibrosis (IPF) . It effectively mitigates IPF-related processes, including TGF-β-induced epithelial-mesenchymal transition (EMT) and fibroblast-to-myofibroblast transition (FMT), as well as profibrotic M2 polarization. Antifibrotic agent 1 selectively inhibits CSF-1R, PDGFR-α, and Src family kinases (SFKs), while sparing VEGFR, FGFR, and Abl to minimize off-target toxicity. In a bleomycin (BLM) -induced pulmonary fibrosis mouse model, it demonstrates strong antifibrotic activity.
Molecular Formula
C27H23ClN6O2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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