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Dasatinib derivative 1

CAT: 0804-HY-176049-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-176049-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dasatinib derivative 1 (2e) effectively releases NO and increases the concentration of 3′,5′-cyclic guanosine monophosphate, as well as maintains senolytic activity. Dasatinib derivative 1 (2e) can be used in the research for chronic ocular hypertension (COHT) glaucoma[1].
CAS Number
3079237-53-6
UNSPSC
12352005
Target
Drug Derivative
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.74
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=[N+](ON=C1OCCOCCOC(CCC(OCCN2CCN(CC2)C3=NC(C)=NC(NC4=NC=C(S4)C(NC5=C(C=CC=C5Cl)C)=O)=C3)=O)=O)[O-])(C6=CC=CC=C6)=O.OS(=O)(C)=O.OS(=O)(C)=O.OS(=O)(C)=O
Molecular Formula
C41H54ClN9O20S5
Molecular Weight
1188.69
References & Citations
[1]Zhongshu Pan, et al. Identification of Nitric Oxide Donating Dasatinib Derivatives with Intraocular Pressure Lowering and Senolytic Activities. J Med Chem. 2025 Apr 24;68 (8) :8600-8617.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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