DPP8/9-IN-1

• Description:

  DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidases 8 and 9 (DPP8/9) with IC50 values of 14 and 298 nM, respectively. DPP8/9-IN-1 binds irreversibly to the active site serine (S730 in DPP9) via a phosphonate warhead and blocks substrate binding to inhibit DPP8/9-mediated protein processing. DPP8/9-IN-1 is promising for research of cancers and inflammatory diseases[1].

• UNSPSC:

  12352005

• Target:

  Dipeptidyl Peptidase

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer; Inflammation/Immunology

• Smiles:

  N[C@@H]1C(N(P(OCC)(CCSC(C=C2)=CC=C2CCCCC)=O)CCC1)=O

• Molecular Formula:

  C20H33N2O3PS

• Molecular Weight:

  412.53

• References & Citations:

  [1]Sewald L, et al. Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors. Nat Commun. 2025 Apr 3;16 (1) :3208.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  DPP-8; DPP-9