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Antimycobacterial agent-12

CAT: 0804-HY-175987Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175987Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antimycobacterial agent-12 (Compound Ec42), a derivative of Platensimycin , is a dual-functional inhibitor KasA and KasB. Antimycobacterial agent-12 has antibacterial activity with a MICs of 2, 2 and 4 μg/mL against Staphylococcus aureus ATCC 29213, Mycobacterium smegmatis and its Isoniazid (HY-B0329) -resistant strain, respectively. Antimycobacterial agent-12 has a superior antimycobacterial activity in M. smegmatis-infected mouse models. Antimycobacterial agent-12 can be used for tuberculosis research[1].
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(NC1=C(C(C(O)=O)=CC=C1O)O)CC[C@@]2(C(C(SC3=CC=C(C=C3)C4=CC=CC=C4)=C[C@]56[C@H]2[C@@H](O[C@]7(C6)C)C[C@H]7C5)=O)C
Molecular Formula
C36H35NO7S
Molecular Weight
625.73
References & Citations
[1]Liang G, et al. Synthesis and Biological Evaluation of Platensimycin Analogues with Improved Antimycobacterial Activity. J Med Chem. 2025 Sep 25;68 (18) :19567-19583.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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